Inter-ethnic differences in efavirenz CNS toxicity – role of cytochrome P450 2B6 polymorphisms
نویسندگان
چکیده
Background Highly active antiretroviral therapy regimens that include efavirenz are effective, but adverse events are common, especially central nervous system (CNS) toxicities. We previously showed increased discontinuation rates of efavirenz due to CNS toxicities in Malay and Chinese patients in our Treat Asia HIV Observational Database (TAHOD) database. We postulate that these differences may be due to genetic differences.
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عنوان ژورنال:
دوره 12 شماره
صفحات -
تاریخ انتشار 2012